Multiwell cell culture plate format with integrated microfluidic perfusion system

Karel Domansky; Walker Inman; Jim Serdy; Linda G. Griffith

doi:10.1117/12.655686

23 January 2006 Multiwell cell culture plate format with integrated microfluidic perfusion system

Karel Domansky, Walker Inman, Jim Serdy, Linda G. Griffith

Proceedings Volume 6112, Microfluidics, BioMEMS, and Medical Microsystems IV; 61120F (2006) https://doi.org/10.1117/12.655686
Event: MOEMS-MEMS 2006 Micro and Nanofabrication, 2006, San Jose, California, United States

Abstract

A new cell culture analog has been developed. It is based on the standard multiwell cell culture plate format but it provides perfused three-dimensional cell culture capability. The new capability is achieved by integrating microfluidic valves and pumps into the plate. The system provides a means to conduct high throughput assays for target validation and predictive toxicology in the drug discovery and development process. It can be also used for evaluation of long-term exposure to drugs or environmental agents or as a model to study viral hepatitis, cancer metastasis, and other diseases and pathological conditions.

Citation Download Citation

Karel Domansky, Walker Inman, Jim Serdy, and Linda G. Griffith "Multiwell cell culture plate format with integrated microfluidic perfusion system", Proc. SPIE 6112, Microfluidics, BioMEMS, and Medical Microsystems IV, 61120F (23 January 2006); https://doi.org/10.1117/12.655686

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