1 March 2006 Planar single-molecule sensors based on hollow-core ARROW waveguides
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Abstract
We discuss the development of novel integrated optical sensors with single molecule detection sensitivity. These sensors are based on liquid-core antiresonant reflecting optical waveguides (ARROWs) that allow for simultaneously guiding light and molecules in liquid solution through micron-sized channels on a chip. Using liquid-core ARROWs as the main building block, two-dimensional planar sensor arrays with sensitivity down to the single molecule level can be fabricated. We present the basic design principle for ARROW waveguides and methods to improve waveguide loss. The influence of surface roughness on the waveguide loss is described. We discuss highly efficient fluorescence detection in both one and two dimensional planar waveguide geometries. Avenues towards subsequent integration with microfluidic systems are presented.
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Dongliang Yin, Dongliang Yin, John P. Barber, John P. Barber, Evan Lunt, Evan Lunt, Dmitri Ermolenko, Dmitri Ermolenko, Harry Noller, Harry Noller, Aaron R. Hawkins, Aaron R. Hawkins, Holger Schmidt, Holger Schmidt, } "Planar single-molecule sensors based on hollow-core ARROW waveguides", Proc. SPIE 6125, Silicon Photonics, 61250Q (1 March 2006); doi: 10.1117/12.648570; https://doi.org/10.1117/12.648570
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