6 March 2006 Investigation of photodynamic activity of water-soluble porphyrins in vitro and in vivo
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Abstract
Photodynamic therapy (PDT) is the method of photosensitized tumor treatment. It is based on the photosensitizer (PS) selective accumulation in tumors, its subsequent activation under the light influence and oxygen active form formation that results in tumor destruction. Photodynamic action of some new water-soluble porphyrins was investigated in our laboratory. Dose-dependent effect of these porphyrins was shown on PC-12 murine pheochromocytoma cell line. The results revealed that the efficiency of the investigated porphyrins decreased in the following way: TOEPyP (meso-tetra-(4-N-oxyethylpyridyl)porphyrin) > Zn-TOEPyP > Ag-TOEPyP. It was shown that TOEPyP possessed nearly the same photodynamic activity (LD50) as well-known photosensitizer chlorin e6. These porphyrins have also demonstrated quite high photodynamic activity in vivo. The results were obtained in the experiments on white mice with engrafted C-180 (Croker's sarcoma). Antitumor activity of these porphyrins in the dark was 30-40%, whereas photodynamic activity was 45-60%.
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Grigor V. Gyulkhandanyan, Grigor V. Gyulkhandanyan, Sona S. Ghambaryan, Sona S. Ghambaryan, Gayane V. Amelyan, Gayane V. Amelyan, Robert K. Ghazaryan, Robert K. Ghazaryan, Flora H. Arsenyan, Flora H. Arsenyan, Aram G. Gyulkhandanyan, Aram G. Gyulkhandanyan, } "Investigation of photodynamic activity of water-soluble porphyrins in vitro and in vivo", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613911 (6 March 2006); doi: 10.1117/12.645053; https://doi.org/10.1117/12.645053
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