Translator Disclaimer
6 March 2006 Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells
Author Affiliations +
Abstract
Ten trans-A2B and A3-type corrole photosensitizers carrying functional groups were synthesized and screened for PDT activities. Photocytotoxicity was measured by the MTT cell reduction assay on a cultured human nasopharyngeal carcinoma (NPC) cell line (HONE-1). Experimental results indicated that corroles containing a single hydroxyphenyl substituent (3, 4 and 5) exhibit the highest activity among the corrole derivatives investigated. Confocal microscopy revealed that the site of cellular localization of the photosensitizers is predominantly at mitochondria. Also, nuclear staining detected apoptotic cell death.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Chi K. Chang, Pak-Wing Kong, Hai-Yang Liu, Lam-Lung Yeung, Ho-Kee Koon, and Nai-Ki Mak "Synthesis and photodynamic activities of modified corrole derivatives on nasopharyngeal carcinoma cells", Proc. SPIE 6139, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XV, 613915 (6 March 2006); https://doi.org/10.1117/12.646328
PROCEEDINGS
11 PAGES


SHARE
Advertisement
Advertisement
Back to Top