Constrained triple-component T2 quantification in vivo

Jinesh J. Jain; Wilburn E. Reddick

doi:10.1117/12.653969

13 March 2006 Constrained triple-component T2 quantification in vivo

Jinesh J. Jain, Wilburn E. Reddick

Proceedings Volume 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images; 61431X (2006) https://doi.org/10.1117/12.653969
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

T₂ relaxation decay curves from in vivo human brain tissue are rarely mono-exponential due to both physiology and partial volume averaging. We propose a tri-exponential model, parametric fitting of the T₂ relaxation curve, restricting the range for the T₂ in each compartment, and estimating the probability of the existence of each of the components on a voxel-by-voxel basis. The model quantifies the T₂ into three discrete compartments: Myelin (T₂ short = 20-50 ms), White / Gray Matter (T₂ middle = 50-120 ms), and CSF (T₂ long = 120-500 ms). A constrained nonlinear minimization technique using subspace trust-region methods was implemented. A voxel-by-voxel analysis was performed, and for any given voxel, the three T₂ components were forced to lie within each compartment. However, the magnitude for each of these components was allowed to take any non-negative value including zero. As a result, if any component were absent, its magnitude would be zero and hence not contribute to the fit. Results from the processing of six healthy normal adults, imaged on a 3T magnet with clinically viable imaging protocols, have been presented and are shown to be in excellent agreement with reported values. This technique is robust and accurate and may potentially be useful in aiding clinical diagnosis and follow-up of patients with white matter abnormalities.

Citation Download Citation

Jinesh J. Jain and Wilburn E. Reddick "Constrained triple-component T2 quantification in vivo", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431X (13 March 2006); https://doi.org/10.1117/12.653969

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