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13 March 2006Regional gray matter abnormalities in patients with schizophrenia determined with optimized voxel-based morphometry
This study examined regional gray matter abnormalities across the whole brain in 19 patients with schizophrenia (12 males and 7 females), comparing with 11 normal volunteers (7 males and 4 females). The customized brain templates
were created in order to improve spatial normalization and segmentation. Then automated preprocessing of magnetic
resonance imaging (MRI) data was conducted using optimized voxel-based morphometry (VBM). The statistical voxel based analysis was implemented in terms of two-sample t-test model. Compared with normal controls, regional gray matter concentration in patients with schizophrenia was significantly reduced in the bilateral superior temporal gyrus, bilateral middle frontal and inferior frontal gyrus, right insula, precentral and parahippocampal areas, left thalamus and hypothalamus as well as, however, significant increases in gray matter concentration were not observed across the whole brain in the patients. This study confirms and extends some earlier findings on gray matter abnormalities in schizophrenic patients. Previous behavior and fMRI researches on schizophrenia have suggested that cognitive capacity
decreased and self-conscious weakened in schizophrenic patients. These regional gray matter abnormalities determined through structural MRI with optimized VBM may be potential anatomic underpinnings of schizophrenia.
XiaoJuan Guo,Li Yao,Zhen Jin, andKewei Chen
"Regional gray matter abnormalities in patients with schizophrenia determined with optimized voxel-based morphometry", Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431Y (13 March 2006); https://doi.org/10.1117/12.651558
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XiaoJuan Guo, Li Yao, Zhen Jin, Kewei Chen, "Regional gray matter abnormalities in patients with schizophrenia determined with optimized voxel-based morphometry," Proc. SPIE 6143, Medical Imaging 2006: Physiology, Function, and Structure from Medical Images, 61431Y (13 March 2006); https://doi.org/10.1117/12.651558