10 March 2006 Image-based metrology of porous tissue engineering scaffolds
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Tissue engineering is an interdisciplinary effort aimed at the repair and regeneration of biological tissues through the application and control of cells, porous scaffolds and growth factors. The regeneration of specific tissues guided by tissue analogous substrates is dependent on diverse scaffold architectural indices that can be derived quantitatively from the microCT and microMR images of the scaffolds. However, the randomness of pore-solid distributions in conventional stochastic scaffolds presents unique computational challenges. As a result, image-based characterization of scaffolds has been predominantly qualitative. In this paper, we discuss quantitative image-based techniques that can be used to compute the metrological indices of porous tissue engineering scaffolds. While bulk averaged quantities such as porosity and surface are derived directly from the optimal pore-solid delineations, the spatially distributed geometric indices are derived from the medial axis representations of the pore network. The computational framework proposed (to the best of our knowledge for the first time in tissue engineering) in this paper might have profound implications towards unraveling the symbiotic structure-function relationship of porous tissue engineering scaffolds.
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Srinivasan Rajagopalan, Srinivasan Rajagopalan, Richard A. Robb, Richard A. Robb, } "Image-based metrology of porous tissue engineering scaffolds", Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61441L (10 March 2006); doi: 10.1117/12.653938; https://doi.org/10.1117/12.653938

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