21 July 2006 Monitoring of drug diffusion in ocular tissues
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There is increasing interest in determining drug diffusion rates in ocular tissues. In this paper we present results of our pilot investigation of depth-resolved monitoring of water diffusion in rabbit cornea using Optical Coherence Tomography (OCT) technique. We monitored changes in the local scattering coefficient of rabbit cornea in vitro as water propagated inside the tissue. Tissue hydration and saturation phases were clearly seen. The water diffusion rate was about 1.48-5cm/sec. The experimental results suggest that water diffusion rate in cornea can be potentially measured with the OCT system noninvasively with high precision and accuracy.
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Mohamad G. Ghosn, Mohamad G. Ghosn, Yezeng Cheng, Yezeng Cheng, Kirill V. Larin, Kirill V. Larin, "Monitoring of drug diffusion in ocular tissues", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616303 (21 July 2006); doi: 10.1117/12.696929; https://doi.org/10.1117/12.696929

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