21 July 2006 Longitudinal 3-week tracking of blood glucose concentration from thermo-optical response measurements on human skin
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Proceedings Volume 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII; 61630R (2006); doi: 10.1117/12.697065
Event: Saratov Fall Meeting 2005, 2005, Saratov, Russian Federation
Abstract
We designed a dual-sensor instrument for measuring optical signals from the arms of human volunteers. The instrument had two temperature-controlled localized reflectance optical probes. Each probe had one illumination fiber and four detection fibers at different source-detector distances. The two probes were maintained at 30 °C. Thirty seconds after contact with the skin one was heated and the other was cooled at the same rate. The effect of heating and cooling on the signal was measured and correlated with blood glucose concentration. The measurements were performed 3 to 5 times a day for each volunteer over the span of three weeks. The data points from the first two weeks were used to establish a calibration model for each volunteer, which was used to predict glucose values from the third week optical data. Successftil calibration was possible for two of the three volunteers.
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Shu-jen Yeh, Stan Kantor, Charles Hanna, Eric Shain, Ronald Hohs, Omar S. Khalil, "Longitudinal 3-week tracking of blood glucose concentration from thermo-optical response measurements on human skin", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 61630R (21 July 2006); doi: 10.1117/12.697065; https://doi.org/10.1117/12.697065
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KEYWORDS
Glucose

Calibration

Blood

Reflectivity

Skin

Data modeling

Tissue optics

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