21 July 2006 Optical clearing of skin tissue produced by application of glucose solution: in vivo study
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Abstract
We present experimental results on optical properties of the human skin controlled by administration ofthe 40%-glucose solution. In vivo reflectance spectra of the human skin were measured. Results of the experimental study of influence of the 40%-glucose solution on reflectance spectra of the human skin are presented. A significant decrease of reflectance of the human skin under action of the osmotic agent is demonstrated. The experiments show that administration of the glucose solution allows for effective control of tissue optical characteristics, that makes skin more transparent, thereby increasing the ability of light penetration through the tissue. Laser Doppler flowmetry has been used for study of skin blood microcirculation under the action of the glucose solution. Results of the experiments demonstrated that at the action of the glucose solution blood perfusion and blood concentration increase, however the mean blood velocity does not change. The presented results can be used in developing functional imaging techniques, including OCT and reflectance spectroscopy. A potential benefit of the optical clearing technique is the improvement of laser therapeutic techniques that rely on sufficient light penetration to a target embedded in tissue.
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Alexey N. Bashkatov, Alexander N. Korolevich, Mikhail M. Stolnitz, Elina A. Genina, Valery V. Tuchin, Yuri P. Sinichkin, Nataly S. Dubina, Sergey I. Vecherinski, Michael S. Belsley, "Optical clearing of skin tissue produced by application of glucose solution: in vivo study", Proc. SPIE 6163, Saratov Fall Meeting 2005: Optical Technologies in Biophysics and Medicine VII, 616313 (21 July 2006); doi: 10.1117/12.697313; https://doi.org/10.1117/12.697313
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