In order to increase the spatial resolve of measuring the optical properties of local tissue, the source-detector separation
should be decreased. However, in this case, the diffuse approximation theory is invalid to describe the photon migration of
local tissue, and could not use to attain the optical properties of tissue from the reflectance measurements. The Monte-Carlo
method is used to simulate the photon migration in turbid media, but the inverse problem is very complex. Therefore, we try
to give an approximation formula to describe the photon migration in this condition and attain the optical properties. In this
paper, a novel optical detecting system was introduced to measure the optical properties of local tissue, which employed 1-D
fiber array, and the maximum of light source-detector separation to collecting fiber can be confined in 1 mm. Based on the
measurement of the different concentration intralipid, and an empiristic model was established to show the relationship
between the separator-dependant reflectance and optical properties, which well agreed with Monte-Carlo simulation.
Ulteriorly, the optical properties were derived from the empiristic model, the error from this approximation theory were
analyzed. The results demonstrate that the empiristic theory can be used to describe the photon migration in local tissue and
rapidly acquire the optical properties of local tissue.