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15 March 2006Characterization of malaria infected blood cells by scanning confocal laser and acoustic vector contrast microscopy
Acoustic and optical multiple contrast microscopy has been employed in order to explore characterizable parameters of
red blood cells, including cells infected by the parasite Plasmodium falciparum, in order to investigate cellular
modifications caused by the infection and to identify possible detection schemes for disease monitoring. Imaging
schemes were based on fluorescence, optical transmission, optical reflection, and amplitude and phase of ultrasound
reflected from the cells. Contrast variations observed in acoustic microscopy, but not in optical microscopy, were
tentatively ascribed to changes caused by the infection.
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E. T. Ahmed Mohamed, S. Schubert, T. W. Gilberger, A. Kamanyi Jr., R. Wannemacher, W. Grill, "Characterization of malaria infected blood cells by scanning confocal laser and acoustic vector contrast microscopy," Proc. SPIE 6177, Health Monitoring and Smart Nondestructive Evaluation of Structural and Biological Systems V, 617716 (15 March 2006);