19 May 2006 Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency
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Abstract
The effect of D-pantethine and L-carnosine on the rate of UV-induced (XeC1 laser λ = 308 nm) aggregation of a mixture of βL-crystallin and α-crystallin is studied. We also demonstrate that the suggested by us combination of short-chain peptides shows better protective properties with respect to UV-induced aggregation than known anti-cataract agents.
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L. V. Soustov, L. V. Soustov, E. V. Chelnokov, E. V. Chelnokov, N. M. Bityurin, N. M. Bityurin, A. L. Kiselev, A. L. Kiselev, V. V. Nemov, V. V. Nemov, Yu. V. Sergeev, Yu. V. Sergeev, M. A. Ostrovsky, M. A. Ostrovsky, } "Study of molecular mechanisms of UV-induced aggregation of crystallins and possibility of maintaining eye lens transparency", Proc. SPIE 6257, ICONO 2005: Nonlinear Laser Spectroscopy, High Precision Measurements, and Laser Biomedicine and Chemistry, 62570X (19 May 2006); doi: 10.1117/12.678391; https://doi.org/10.1117/12.678391
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