The novel results of the R & D activity of TDI SIE SB RAS in the field of the optical measuring technologies, as well as laser technologies for solving safety problems are presented. To measure the rocks stress and to prevent the mountain impact, as well as for basic investigations, a set of optical-electronic deformers and systems was developed and produced. For permanent noncontact bearing position inspection of oil-drilling platforms on Sakhalin coast (Russia) we have developed optical-electronic method and system SAKHALIN with cumulative traveled distance (3 km) measurement error less than 0.03 %. Multifunctional laser technological system LSP-2000 equipped by two Nd-YAG lasers was developed for cutting, welding and surface micro profiling with ablation process (working range of 3 × 2 × 0.6 m3, positioning error less than 10 mkm). Safety of Russian nuclear reactors takes 100 % noncontact 3D dimensional inspection of all parts of fuel assemblies, including grid spacers. Results of development and testing the specialized high productive laser measuring machine, based on structured illumination, for 3D inspection of grid spacers with micron resolution are presented. Ensuring the safety of running trains is the actual task for railways. Using high-speed laser noncontact method on the base of triangulation position sensors, TDI SIE has developed and produced automatic laser diagnostic system COMPLEX for inspection of geometric parameters of wheel pairs (train speed up to 60 km/hr.), which is used successfully on Russian railways. Experimental results on measuring and laser technological systems testing are presented.