12 September 2006 Automated laser spectrofluorimeter for monitoring of myocardial metabolism
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Abstract
Methods of optical biopsy have a series of advantages before other methods of clinical diagnostics. The high accuracy of received results enables registration even small change of concentration of substances, and the opportunity of remote registration makes methods optical biopsy by an optimum means for noninvasive methods of diagnostics in medicine. The method of the fluorescent analysis allows to investigate dynamics of changes of a functional condition of organs and tissue in norm and pathologies, called by the various factors (an inflammation, ischemia, degenerative changes). Bring the results of development of expiremental setup for the laser fluorescent analysis of physiological and functional condition of various organs and tissue of organism. In expiremental setup was used pulse UF nitric laser with length of wave generation = 337 nm. For delivery of radiation to tissue, and, also, collection of a radiation of fluorescence were used various optic fiber scheme. The expiremental setup includes automated tunable monochromator and ADC, receiving a signal from photomultiplier tube. Driving of all blocks and processing of results is realize on IBM-compatible computer with the appropriate software. Was used the synchronous detecting for reducing of a background signal. Myocard at surgical introoperation by an accompanied condition of sharp ischemia was researches on these expiremental setup. Spectrofluorimetric criteria of an estimation of a condition of viscus at peritonitis were development.
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A. Yu. Popov, A. Yu. Popov, V. V. Salmin, V. V. Salmin, A. A. Fursov, A. A. Fursov, A. V. Stepanenko, A. V. Stepanenko, A. G. Sokolovich, A. G. Sokolovich, A. B. Salmina, A. B. Salmina, A. A. Rebenkova, A. A. Rebenkova, R. A. Makarov, R. A. Makarov, A. S. Provorov, A. S. Provorov, } "Automated laser spectrofluorimeter for monitoring of myocardial metabolism", Proc. SPIE 6284, International Conference on Lasers, Applications, and Technologies 2005: Laser Technologies for Environmental Monitoring and Ecological Applications, and Laser Technologies for Medicine, 62840J (12 September 2006); doi: 10.1117/12.714171; https://doi.org/10.1117/12.714171
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