14 August 2006 Applications of imaging interferometry
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Here we report application of imaging interferometry to the study of nanomechanical motion in biosensors and living biological systems. Using strobed interferometric microscopy we are able to probe the dynamic behavior of individual (100 x 500 x 1 micron) cantilevers in an eight cantilever array over frequencies from 0 - 1 MHz. In a related approach, we have developed an interferometric method to measure cell-specific mechanical signals in real time. This yields real-time diagnostic information about cell structure, metabolism and movement, along with response to chemical and physical stimuli. Our new approach makes use of "nanomirrors" fixed to the cell membrane. These mirrors act as nanoscopic displacement probes and can be interrogated, rapidly, by optical profiling metrology.
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Jason Reed, Jason Reed, Paul Wilkinson, Paul Wilkinson, Keith O'Doherty, Keith O'Doherty, Joanna Schmit, Joanna Schmit, Sen Han, Sen Han, Josh Troke, Josh Troke, Michael Teitell, Michael Teitell, William Klug, William Klug, James Gimzewski, James Gimzewski, } "Applications of imaging interferometry", Proc. SPIE 6293, Interferometry XIII: Applications, 629301 (14 August 2006); doi: 10.1117/12.683948; https://doi.org/10.1117/12.683948

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