Adaptive plasticity in mammalian masticatory joints

Matthew J. Ravosa; Ravinder Kunwar; Elisabeth K. Nicholson; Emily B. Klopp; Jessie Pinchoff; Stuart R. Stock; M. Sharon Stack; Mark W. Hamrick

doi:10.1117/12.680580

7 September 2006 Adaptive plasticity in mammalian masticatory joints

Matthew J. Ravosa, Ravinder Kunwar, Elisabeth K. Nicholson, Emily B. Klopp, Jessie Pinchoff, Stuart R. Stock, M. Sharon Stack, Mark W. Hamrick

Author Affiliations +

Proceedings Volume 6318, Developments in X-Ray Tomography V; 63180D (2006) https://doi.org/10.1117/12.680580
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

Genetically similar white rabbits raised on diets of different mechanical properties, as well as wild-type and myostatin-deficient mice raised on similar diets, were compared to assess the postweaning effects of elevated masticatory loads due to increased jaw-adductor muscle and bite forces on the proportions and properties of the mandibular symphysis and temporomandibular joint (TMJ). Microcomputed tomography (microCT) was used to quantify bone structure at a series of equidistant external and internal sites in coronal sections for a series of joint locations. Discriminant function analyses and non-parametric ANOVAs were used to characterize variation in biomineralization within and between loading cohorts. In both species, long-term excessive loading results in larger joint proportions, thicker articular and cortical bone, and increased biomineralization of hard tissues. Such adaptive plasticity appears designed to maintain the postnatal integrity of masticatory joint systems for a primary loading environment(s). This behavioral signal may be increasingly mitigated in older organisms by the interplay between adaptive and degradative joint tissue responses.

Citation Download Citation

Matthew J. Ravosa, Ravinder Kunwar, Elisabeth K. Nicholson, Emily B. Klopp, Jessie Pinchoff, Stuart R. Stock, M. Sharon Stack, and Mark W. Hamrick "Adaptive plasticity in mammalian masticatory joints", Proc. SPIE 6318, Developments in X-Ray Tomography V, 63180D (7 September 2006); https://doi.org/10.1117/12.680580

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