Development of bioluminescence tomography

Ming Jiang; Tie Zhou; Jiantao Cheng; Wenxiang Cong; Ge Wang

doi:10.1117/12.680720

7 September 2006 Development of bioluminescence tomography

Ming Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, Ge Wang

Proceedings Volume 6318, Developments in X-Ray Tomography V; 63180E (2006) https://doi.org/10.1117/12.680720
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

The bioluminescence tomography (BLT) emerges as a novel molecular imaging technology for small animal studies. BLT is an ill-posed inverse source problem subject to Cauchy data of the diffusion model. Several algorithms were developed to regularize this problem. Although those algorithms produce encouraging results, they theoretically require the completely measured data on the external surface. In practice, the observed data is often incomplete due to physical limitations. The BLT problem in this situation is similar to limited angle X-ray CT although the imaging model is more complicated with BLT. In this work, we formulate a mathematical model for BLT from partial data and generalize our previous results on the solution uniqueness to the partial data case. Also, we extend our previous methods to handle incomplete data. The first method is a variant of the well-known EM algorithm. The second one is based on the Landweber scheme. Both methods allow incorporation of knowledge-based constraints. Numerical and physical phantoms are used to evaluate and validate the proposed algorithms.

Citation Download Citation

Ming Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, and Ge Wang "Development of bioluminescence tomography", Proc. SPIE 6318, Developments in X-Ray Tomography V, 63180E (7 September 2006); https://doi.org/10.1117/12.680720

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available