Feasibility studies of an EMCCD-based beta imaging probe for radioguided thyroid surgery

Irina Shestakova; Vivek V. Nagarkar; Valeriy Gaysinskiy; Gerald Entine; Brendan C. Stack; Brian Miller

doi:10.1117/12.687622

30 August 2006 Feasibility studies of an EMCCD-based beta imaging probe for radioguided thyroid surgery

Irina Shestakova, Vivek V. Nagarkar, Valeriy Gaysinskiy, Gerald Entine, Brendan C. Stack, Brian Miller

Proceedings Volume 6319, Hard X-Ray and Gamma-Ray Detector Physics and Penetrating Radiation Systems VIII; 63191E (2006) https://doi.org/10.1117/12.687622
Event: SPIE Optics + Photonics, 2006, San Diego, California, United States

Abstract

We are developing a probe for image-guided surgery of cancer to be used in conjunction with traditional beta emitting radiopharmaceuticals such as I¹³¹ and F¹⁸-FDG. This device is based on a combination of two novel technologies, a microcolumnar film scintillator, CsI(Tl) and low-noise high sensitivity Electron-Multiplying CCD (EMCCD). The former allows high spatial resolution nuclear imaging and the latter facilitates detection of signal with significantly higher SNR than conventional CCDs by the virtue of internal signal gain built into its readout register. CsI(Tl) is bonded to the EMCCD via a flexible coherent fiberopic cable for easy handling. Due to its high sensitivity the probe is capable of functioning in real time providing high spatial resolution nuclear images for precise detection, delineation and excision of tumors. The evaluation of the probe using standard clinical phantoms as well as the operational data obtained on swine models and in clinical surgery will be presented.

Citation Download Citation

Irina Shestakova, Vivek V. Nagarkar, Valeriy Gaysinskiy, Gerald Entine, Brendan C. Stack, and Brian Miller "Feasibility studies of an EMCCD-based beta imaging probe for radioguided thyroid surgery", Proc. SPIE 6319, Hard X-Ray and Gamma-Ray Detector Physics and Penetrating Radiation Systems VIII, 63191E (30 August 2006); https://doi.org/10.1117/12.687622

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