In this manuscript we describe the manipulation of surface plasmon polariton (SPP) modes excited in a two
dimensional periodic nanohole array scattering structure by tuning the fluid over the metal surface. We describe the
fabrication processes for making large area periodic nanohole arrays, and a soft lithography process for the addition of
microfluidic channels. We then show the tuning of various modes and the application for such structures as
multichannel, imaging SPP sensors.