12 July 2006 Dynamic-focusing microscope objective for optical coherence tomography
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Proceedings Volume 6342, International Optical Design Conference 2006; 63420H (2006) https://doi.org/10.1117/12.692205
Event: International Optical Design Conference 2006, 2006, Vancouver, BC, Canada
Optical Coherence Tomography (OCT) is a novel optical imaging technique that has assumed significant importance in bio-medical imaging in the last two decades because it is non-invasive and provides accurate, high resolution images of three dimensional cross-sections of body tissue, exceeding the capabilities of the current predominant imaging technique - ultrasound. In this paper, the application of high resolution OCT, known as optical coherence microscopy (OCM) is investigated for in vivo detection of abnormal skin pathology for the early diagnosis of cancer. A main challenge in OCM is maintaining invariant resolution throughout the sample. The technology presented is based on a dynamic focusing microscope imaging probe conceived for skin imaging and the detection of abnormalities in the epithelium. A novel method for dynamic focusing in the biological sample is presented using variable-focus lens technology to obtain three dimensional images with invariant resolution throughout the cross-section and depth of the sample is presented and discussed. A low coherence broadband source centered at near IR wavelengths is used to illuminate the sample. The design, analysis and predicted performance of the dynamic focusing microscope objective designed for dynamic three dimensional imaging at 5μm resolution for the chosen broadband spectrum is presented.
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Supraja Murali, Supraja Murali, Jannick Rolland, Jannick Rolland, } "Dynamic-focusing microscope objective for optical coherence tomography", Proc. SPIE 6342, International Optical Design Conference 2006, 63420H (12 July 2006); doi: 10.1117/12.692205; https://doi.org/10.1117/12.692205

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