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8 September 2006 Functional thermal lens microscopes for ultrasensitive analysis of non-fluorescent molecules and microchip chemistry
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Proceedings Volume 6343, Photonics North 2006; 63430C (2006) https://doi.org/10.1117/12.707488
Event: Photonics North 2006, 2006, Quebec City, Canada
Abstract
Thermal lens microscope (TLM) is a kind of absorption spectrophotometry based on photothermal phenomena of non-fluorescent molecules. TLM has high sensitivity (single molecule concentration in fL detection volume) and wide applicability (non-fluorescent molecules). TLM was successfully applied to detection on microchip in clinical diagnosis, environmental analysis, single cell analysis and so on. The basic function of TLM is concentration determination in microspace. In addition, we have realized various functions on TLM for sensitive chiral analysis, individual nanoparticle counting and in situ flow sensing. In this presentation, we explain these functional TLMs for microchip chemistry.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Kazuma Mawatari and Takehiko Kitamori "Functional thermal lens microscopes for ultrasensitive analysis of non-fluorescent molecules and microchip chemistry", Proc. SPIE 6343, Photonics North 2006, 63430C (8 September 2006); https://doi.org/10.1117/12.707488
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