20 October 2006 Real-time control of microreactors by Raman spectroscopy
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Proceedings Volume 6371, Photonic Sensing Technologies; 637106 (2006) https://doi.org/10.1117/12.682536
Event: Optics East 2006, 2006, Boston, Massachusetts, United States
Abstract
In recent years a paradigm in chemical manufacturing has emerged, numbering-up production instead of the traditional scaling-up. This new approach employs nanoliter to milliliter reactors that increase control of reaction pathways, product choice and yield. These small-scale reactors virtually eliminate mixing and heat transfer problems associated with large-scale reactors that often limit yield. The value of small-scale reactors is being recognized by the pharmaceutical industry where only small-scale synthesis is required until clinical trials are complete, at which time fullscale production needs to be accomplished in the shortest possible time. One of the most often used reaction steps during the synthesis of pharmaceuticals is protecting carboxylic acid groups by esterification. We have been developing Raman spectroscopy as a process analytical tool to monitor and control chemistry in such small-scale reactors. Here we present Raman spectra of the esterification of benzoic acid performed in a 5-mL batch reactor.
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Chetan Shende, Paul Maksymiuk, Frank Inscore, Stuart Farquharson, "Real-time control of microreactors by Raman spectroscopy", Proc. SPIE 6371, Photonic Sensing Technologies, 637106 (20 October 2006); doi: 10.1117/12.682536; https://doi.org/10.1117/12.682536
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