3 November 2006 Highly sensitive single photon detection system for multi-lane DNA sequencer
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Proceedings Volume 6372, Advanced Photon Counting Techniques; 63720B (2006) https://doi.org/10.1117/12.685404
Event: Optics East 2006, 2006, Boston, Massachusetts, United States
Abstract
A multichannel fluorescence detection system for multi-lane DNA sequencer based on single photon counting is presented. The problem of elimination of the lane cross-talk caused by both optical and electronic cross-talk between the detection lanes is discussed. A novel method for elimination of the channel cross-talk is proposed. The calibration procedure for a DNA sequencer with lane cross-talk cancellation is described. Improvement in sensitivity of a DNA sequencer setup by introducing wide collection angle optical system is discussed.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Dmitri Gavrilov, Dmitri Gavrilov, Boris Gorbovitski, Boris Gorbovitski, Georgiy Gudkov, Georgiy Gudkov, Andrey Stepukhovich, Andrey Stepukhovich, Marina Tcherevishnik, Marina Tcherevishnik, Georgiy Tyshko, Georgiy Tyshko, Andriy Tsupryk, Andriy Tsupryk, Vera Gorfinkel, Vera Gorfinkel, } "Highly sensitive single photon detection system for multi-lane DNA sequencer", Proc. SPIE 6372, Advanced Photon Counting Techniques, 63720B (3 November 2006); doi: 10.1117/12.685404; https://doi.org/10.1117/12.685404
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