Intrinsic Fabry-Perot interferometer with a micrometric tip for biomedical applications

Xingwei Wang; Juncheng Xu; Zhuang Wang; Kristie L. Cooper; Anbo Wang

doi:10.1117/12.685088

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23 October 2006 Intrinsic Fabry-Perot interferometer with a micrometric tip for biomedical applications

Xingwei Wang, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, Anbo Wang

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Proceedings Volume 6380, Smart Medical and Biomedical Sensor Technology IV; 638005 (2006) https://doi.org/10.1117/12.685088
Event: Optics East 2006, 2006, Boston, Massachusetts, United States

Abstract

This paper presents a novel intrinsic fiber optic Fabry-Perot (FP) structure with a micrometric diameter tip. With the FP cavity inside the fiber, the change in optical path length difference (OPD) caused by the environment can be demodulated. With such a tiny protrusion, the sensor can be inserted into micron size cells for intracellular measurements. This label-free detection method is very useful in biological areas such as DNA hybridization detection. It provides a valuable tool for intracellular studies that have applications ranging from medicine to national security. In addition, the fabrication is simple including only cleaving, splicing, and etching. The signal is stable with high visibility. Last but not the least, the structure shows great promise for reduction to nanometric size. Once this goal is achieved, the sensor can be inserted into most cells with minimal invasiveness.

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Xingwei Wang, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, and Anbo Wang "Intrinsic Fabry-Perot interferometer with a micrometric tip for biomedical applications", Proc. SPIE 6380, Smart Medical and Biomedical Sensor Technology IV, 638005 (23 October 2006); https://doi.org/10.1117/12.685088

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