Hollow fiber optic probe for in vivo Raman measurement

Takashi Katagiri; Yusuke Hattori; Yuichi Komachi; Yuji Matsuura; Hideo Tashiro; Hidetoshi Sato

doi:10.1117/12.686634

23 October 2006 Hollow fiber optic probe for in vivo Raman measurement

Takashi Katagiri, Yusuke Hattori, Yuichi Komachi, Yuji Matsuura, Hideo Tashiro, Hidetoshi Sato

Proceedings Volume 6380, Smart Medical and Biomedical Sensor Technology IV; 63800X (2006) https://doi.org/10.1117/12.686634
Event: Optics East 2006, 2006, Boston, Massachusetts, United States

Abstract

A hollow optical fiber Raman probe equipped with a ball lens is developed to study the stomach cancer. The probe generates little Raman scattering or fluorescence noise because the HOF confine light into the air core. In order to maximize the collection efficiency and the spatial resolution, material and size of the ball lens is optimized. The total diameter of the probe head is 0.64 mm. The probe is useful for measurement of layered sample by the contact mode because it has very short focal length and high depth resolution. In vivo experiments in a stomach of a living rat demonstrate the high viability of the probe for noninvasive diagnosis of the stomach cancer.

Citation Download Citation

Takashi Katagiri, Yusuke Hattori, Yuichi Komachi, Yuji Matsuura, Hideo Tashiro, and Hidetoshi Sato "Hollow fiber optic probe for in vivo Raman measurement", Proc. SPIE 6380, Smart Medical and Biomedical Sensor Technology IV, 63800X (23 October 2006); https://doi.org/10.1117/12.686634

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