17 October 2006 Breath acetone detection
Author Affiliations +
Proceedings Volume 6386, Optical Methods in the Life Sciences; 63860O (2006) https://doi.org/10.1117/12.685276
Event: Optics East 2006, 2006, Boston, Massachusetts, United States
Acetone is a good marker of metabolic stress as it is the most volatile and rapidly equilibrated of the ketone bodies produced by human metabolism. If the body utilizes predominately fat to meet its energy requirements, blood and breath acetone concentrations will increase. Elevated concentrations of breath acetone can indicate a normal response to caloric imbalances in the diet, or a diseased state such as untreated diabetes. This paper describes a novel method of acetone detection that uses a gas-solid chemical reaction of acetone with a hydroxylamine hydrochloride (HA) to produce an easily detectable chemical species, HCl. Breath samples are passed through a reactor filled with solid HA and the amount of HCl gas released is measured by sensitive near infrared diode laser spectroscopy. The breath acetone instrument described is compact, low power and portable.
© (2006) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Steve M. Massick, Steve M. Massick, Andrei Vakhtin, Andrei Vakhtin, } "Breath acetone detection", Proc. SPIE 6386, Optical Methods in the Life Sciences, 63860O (17 October 2006); doi: 10.1117/12.685276; https://doi.org/10.1117/12.685276

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