BioMEMS for the determination of rheological properties of biological fluids

Andrei Marius Avram; Marioara Avram; Ciprian Iliescu; Marius Volmer

doi:10.1117/12.705353

20 December 2006 BioMEMS for the determination of rheological properties of biological fluids

Andrei Marius Avram, Marioara Avram, Ciprian Iliescu, Marius Volmer

Author Affiliations +

Proceedings Volume 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III; 64150V (2006) https://doi.org/10.1117/12.705353
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2006, Adelaide, Australia

Abstract

The purpose of this research was to model, design and fabricate a biodynamic analysis microsystem required for the determination of various molecular transport properties of the non-Newtonian biological fluids. In order to achieve this, a lab-on-a-chip device is studied. The microsystem consists of a microchannels system and gear wheels for the rotator pump and for the detection system. The microchannel system developed satisfies the objectives for the study of microcirculation and characterization of cell rheological properties, functions and behavior. The microchannel types are: straight, bifurcated, stenosed and endothelial profiled. Some simulations were made in order to provide an idea about blood flow through blood vessels and microchannels. The gear wheel was fabricated using the silicon surface micromachining technology, combining the undercut and refill technique with pin-joint bearing permitting the fabrication of bushings. A giant magnetoresistive sensor with a non-contacting transduction mechanism, in full Wheatstone bridge configurations with four active resistors in the middle of the sensitive structure and four shielded reference resistors, very attractive for detection of low magnetic fields in lab-on-a-chip applications, is used to transform the rotor rotation rate into an electrical signal.

Citation Download Citation

Andrei Marius Avram, Marioara Avram, Ciprian Iliescu, and Marius Volmer "BioMEMS for the determination of rheological properties of biological fluids", Proc. SPIE 6415, Micro- and Nanotechnology: Materials, Processes, Packaging, and Systems III, 64150V (20 December 2006); https://doi.org/10.1117/12.705353

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