14 December 2006 An electrically controlled micromachined drug delivery device employing two silicon wafers
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Abstract
There is constant interest and research being conducted in devising new means to deliver drugs to the internal organs of the human body to overcome the shortcomings of conventional systems. In this paper we propose a micro fabricated drug delivery system capable of storing drugs in the range of micro-litres (μL) in its secondary reservoir. It will deliver drugs by electrochemical disruption of thin gold membranes. This device is proposed to be integrated in an endoscopic capsule with a view to deliver drugs in areas that are difficult to access, such as the small and large intestines. The design of the device is based on two microfabricated silicon wafers having multiple cavities etched into them. The cavities on the silicon wafers are covered by thin gold membranes. These membranes act as the openings for the release of drugs stored in a secondary reservoir sandwiched between the two silicon wafers. The secondary reservoir is being named so because the cavities in the silicon wafer act as the primary reservoir. The secondary reservoir having holes made in them can be made to align with cavities on the silicon wafers and bonded. On applying suitable voltage, the gold membranes disrupt electrochemically, providing outlets from both sides. The drug diffuses out from both ends of the device.
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Robin Rajan, Robin Rajan, Syed Mahfuzul Aziz, Syed Mahfuzul Aziz, Tharshan Vaithianathan, Tharshan Vaithianathan, } "An electrically controlled micromachined drug delivery device employing two silicon wafers", Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160P (14 December 2006); doi: 10.1117/12.695644; https://doi.org/10.1117/12.695644
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