Single-cell impedance spectroscopy: maximum length sequence analysis

Tao Sun; Nicolas G. Green; Shady Gawad; Hywel Morgan

doi:10.1117/12.696633

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14 December 2006 Single-cell impedance spectroscopy: maximum length sequence analysis

Tao Sun, Nicolas G. Green, Shady Gawad, Hywel Morgan

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Proceedings Volume 6416, Biomedical Applications of Micro- and Nanoengineering III; 64160Y (2006) https://doi.org/10.1117/12.696633
Event: SPIE Smart Materials, Nano- and Micro-Smart Systems, 2006, Adelaide, Australia

Abstract

A novel broadband high-speed impedance spectrometer has been developed for the analysis of single biological particles in a high-throughput microfluidic cytometer. The technique is based on obtaining the impulse response of the system using maximum length sequences (MLS) as the excitation signal. The impulse response is converted into the frequency domain using Fast Fourier Transform (FFT). Theoretical modeling and simulation of a single cell suspended in the cytometer show that the MLS technique is capable of high precision single particle analysis.

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Tao Sun, Nicolas G. Green, Shady Gawad, and Hywel Morgan "Single-cell impedance spectroscopy: maximum length sequence analysis", Proc. SPIE 6416, Biomedical Applications of Micro- and Nanoengineering III, 64160Y (14 December 2006); https://doi.org/10.1117/12.696633

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