23 March 2007 Invariant high resolution optical skin imaging
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Abstract
Optical Coherence Microscopy (OCM) is a bio-medical low coherence interferometric imaging technique that has become a topic of active research because of its ability to provide accurate, non-invasive cross-sectional images of biological tissue with much greater resolution than the current common technique ultrasound. OCM is a derivative of Optical Coherence Tomography (OCT) that enables greater resolution imposed by the implementation of an optical confocal design involving high numerical aperture (NA) focusing in the sample. The primary setback of OCM, however is the depth dependence of the lateral resolution obtained that arises from the smaller depth of focus of the high NA beam. We propose to overcome this limitation using a dynamic focusing lens design that can achieve quasi-invariant lateral resolution up to 1.5mm depth of skin tissue.
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Supraja Murali, Jannick Rolland, "Invariant high resolution optical skin imaging", Proc. SPIE 6424, Photonic Therapeutics and Diagnostics III, 64240V (23 March 2007); doi: 10.1117/12.710932; https://doi.org/10.1117/12.710932
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