5 March 2007 High isotropic resolution PS-OCT for imaging the human retina and cone mosaic in vivo
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Proceedings Volume 6426, Ophthalmic Technologies XVII; 64260J (2007) https://doi.org/10.1117/12.702489
Event: SPIE BiOS, 2007, San Jose, California, United States
Abstract
We present a system for high and isotropic resolution imaging of the retina. A polarization sensitive optical coherence tomography (PS-OCT) instrument with a depth resolution of ~4.5&mgr;m within the retina was used and adapted to achieve a high transverse resolution. The realized transverse resolution was sufficient to resolve the human cone mosaic in vivo without the use of adaptive optics. Since the technique is based on a fast transversal scanning of the retina, scanning laser ophthalmoscope (SLO) images can be acquired simultaneously to OCT images which allows a direct comparison of the two techniques. Furthermore, the system incorporates the possibility of a dynamic shift of focus within the retina which is essential to maintain the high transverse resolution over the whole imaging depth. Using a resonant scanner operated at 4kHz the system is capable to record 8000 transversal lines per second. Backscattered intensity, retardation and fast axis orientation of the human retina are presented with this high isotropic resolution.
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M. Pircher, B. Baumann, E. Götzinger, C. K. Hitzenberger, "High isotropic resolution PS-OCT for imaging the human retina and cone mosaic in vivo", Proc. SPIE 6426, Ophthalmic Technologies XVII, 64260J (5 March 2007); doi: 10.1117/12.702489; https://doi.org/10.1117/12.702489
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