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5 March 2007 Interferometric optical online dosimetry for selective retina treatment (SRT)
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Proceedings Volume 6426, Ophthalmic Technologies XVII; 642619 (2007)
Event: SPIE BiOS, 2007, San Jose, California, United States
In selective retina treatment (SRT) spatial confined tissue damage in the absorbing retinal pigment epithelium (RPE) is obtained by applying microsecond laser pulses. The damage in the RPE is caused by transient microbubbles forming around the laser heated melanin granules inside the cells. For treatment of RPE related diseases, SRT is thought to share the therapeutic benefits of conventional photocoagulation but without affecting the photoreceptors. A drawback for effective clinical SRT is that the laser-induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is demanded in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer which is operated with a laser diode at 830nm. We present current results obtained with porcine RPE explants in vitro and complete porcine eye globes ex vivo.
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Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, and Ralf Brinkmann "Interferometric optical online dosimetry for selective retina treatment (SRT)", Proc. SPIE 6426, Ophthalmic Technologies XVII, 642619 (5 March 2007);

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