27 February 2007 Effect of implanted brachytherapy seeds on optical fluence distribution: preliminary ex vivo study
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Abstract
Photodynamic therapy (PDT) has gradually found its place in the treatment of malignant and non-malignant human diseases. Currently, interstitial PDT is being explored as an alternative modality for newly diagnosed and recurrent organ-confined prostate cancer. The interstitial PDT for the treatment of prostate cancer might be considered to treat prostates with permanent radioactive seeds implantation. However, the effect of implanted brachytherapy seeds on the optical fluence distribution of PDT light has not been studied before. This study investigated, for the first time, the effect of brachytherapy seed on the optical fluence distribution of 760 nm light in ex vivo models (meat and canine prostate).
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Fred W. Hetzel, Qun Chen, Meisong Ding, Francis Newman, Kenneth C. Dole, Zheng Huang, Dominique Blanc, "Effect of implanted brachytherapy seeds on optical fluence distribution: preliminary ex vivo study", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64270J (27 February 2007); doi: 10.1117/12.700756; https://doi.org/10.1117/12.700756
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