Analysis of colon tumors in rats by near-infrared Raman spectroscopy

Janaína Duarte V.D.M.; Raduan Hage V.D.M.; Landulfo Silveira Jr.; Fabricio Silveira; Marcos Tadeu T. Pacheco; Egberto Munin; Hélio Plapler M.D.

doi:10.1117/12.699690

28 February 2007 Analysis of colon tumors in rats by near-infrared Raman spectroscopy

Janaína Duarte V.D.M., Raduan Hage V.D.M., Landulfo Silveira Jr., Fabricio Silveira, Marcos Tadeu T. Pacheco, Egberto Munin, Hélio Plapler M.D.

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Proceedings Volume 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI; 642714 (2007) https://doi.org/10.1117/12.699690
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Biomedical applications of near-infrared Raman spectroscopy have increased their importance at the last ten years. This technique can determinate the molecular composition of materials, allowing a sensible and fast biological diagnosis. It has showed to be a promising tool for health diagnosis due to its high sensibility. Colorectal cancer (CRC) is one of the most common malignant tumors in humans beings. In the last decades many experimental models have been developed in animals based in the use of chemical composites to induce the formation and development of these tumors, many of them present similar characteristics to those of natural occurrence aiming to the attainment of information on genesis, evolution, as well as diagnosis and more efficient therapies for treating these neoplasias. Amongst the most used chemical composites is the 1,2- dimetilhydrazine (DMH) because its morphological and histological similarity to those tumors. This study aims to compare in vivo normal colon tissue and tumoral colon tissue, induced by DMH, in rats by near-infrared Raman spectroscopy to permit the use in the near future for an efficient diagnosis in real time besides being useful as an auxiliary method for several therapies, including the photodynamic therapy.

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Janaína Duarte V.D.M., Raduan Hage V.D.M., Landulfo Silveira Jr., Fabricio Silveira, Marcos Tadeu T. Pacheco, Egberto Munin, and Hélio Plapler M.D. "Analysis of colon tumors in rats by near-infrared Raman spectroscopy", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 642714 (28 February 2007); https://doi.org/10.1117/12.699690

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KEYWORDS

Tumors

Raman spectroscopy

Colon

Tissues

Cancer

Colorectal cancer

In vivo imaging

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