28 February 2007 A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment
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Abstract
Multi-sensory fiber-optic probes using nanocrystals as the sensing materials are shown to overcome most limitations imposed by those using organic dyes as the fluence-rate sensing materials. These nanocrystals are shown to be excitable by a wide range of wavelengths covering the entire tissue transparent window utilized by various light-enabled treatment modalities. The optical response of the sensors made from the nanocrystals is shown to be linear without any sign of photobleaching and sensor crosstalk over a wide range of irradiance and fluence. Fiber probes using the nanocrystals are promising in offering high spatial resolution in fluence-rate dosimetry for photodynamic therapy and photothermal treatment.
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Tung-Wah Frederick Chang, Mari Boesen, Robert Weersink, Luc Charron, Edward H. Sargent, Lothar Lilge, "A versatile nanocrystal-based multi-sensory fiber-optic probe for dosimetry in PDT and thermal treatment", Proc. SPIE 6427, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI, 64271B (28 February 2007); doi: 10.1117/12.701274; https://doi.org/10.1117/12.701274
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