21 February 2007 Advancing to controlled and individualized dosimetry for monochromatic light therapy
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Monochromatic light therapy (MLT) is still not a clinical modality due to conflicting and low predictable outcomes. This likely is due to the mismatch between the accuracy of optical dosimetry employing the theoretically predicted or empirically found dosages and the dynamic requirements of photobiostimulation to dosage. The same doses delivered to a target area can be stimulatory or not depending on the dynamic changes of tissue optical parameters in vivo. Since the optical parameters of tissue and, hence, the radiant energy absorbed in the target area change during the treatment, it is important monitoring and coordinating the dosage with these changes. In this paper we analyze potentials of advancing to dosimetry that meets the dynamic requirements of the MLT to dosage. Both the tissue optical clearing and the feedback control of irradiation are considered. It is pointed out that the key physiological parameter influencing the variability of actual dose is the blood microcirculation. Even the optimal doses of continuous light irradiation may produce negative therapeutic effect at the time when the target tissue is depleted of blood and cannot maintain the energetic requirements of treatment. It is shown that synchronization of irradiation with the patient's pulse and breathing waves excludes cycles of negative responses and individualize the dosage.
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Valentin Grimblatov, Valentin Grimblatov, Alex Goldfarb, Alex Goldfarb, Motyl Shneyder, Motyl Shneyder, } "Advancing to controlled and individualized dosimetry for monochromatic light therapy", Proc. SPIE 6428, Mechanisms for Low-Light Therapy II, 642806 (21 February 2007); doi: 10.1117/12.708759; https://doi.org/10.1117/12.708759

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