7 February 2007 Depth-resolved monitoring of analytes diffusion in ocular tissues
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Abstract
Optical coherence tomography (OCT) is a noninvasive imaging technique with high in-depth resolution. We employed OCT technique for monitoring and quantification of analyte and drug diffusion in cornea and sclera of rabbit eyes in vitro. Different analytes and drugs such as metronidazole, dexamethasone, ciprofloxacin, mannitol, and glucose solution were studied and whose permeability coefficients were calculated. Drug diffusion monitoring was performed as a function of time and as a function of depth. Obtained results suggest that OCT technique might be used for analyte diffusion studies in connective and epithelial tissues.
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Kirill V. Larin, Mohamad G. Ghosn, Valery V. Tuchin, "Depth-resolved monitoring of analytes diffusion in ocular tissues", Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 642918 (7 February 2007); doi: 10.1117/12.698143; https://doi.org/10.1117/12.698143
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