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7 February 2007 Real-time ultrahigh-resolution imaging by dual-channel full-field optical coherence tomography
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A real-time, ultrahigh resolution full-field (FF) optical coherence tomography (OCT) system has been developed using a dual-channel detection technique. Our FF-OCT system is based on a white-light interference microscope combined with a polarization sensitive dual-channel detection technique using a pair of CCD cameras, where a pair of images with 90- degree phase difference are simultaneously captured with an achromatic phase shifter. By acquiring an additional pair of images using a conventional phase shift method, an inphase and a quadrature component of FF-OCT image are acquired by calculating the differences every two consecutive CCD frames. Sum of their squares then yields FF-OCT image. Using the ultrabroad bandwidth of halogen lamp and relatively high-NA objectives, an axial resolution of 1.2 &mgr;m and a transverse resolution of 1.7 &mgr;m have been achieved. Sub-cellular imaging results of porcine conjunctiva and esophagus recorded as fast as 40 ms are presented.
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Masahiro Akiba and Kin Pui Chan "Real-time ultrahigh-resolution imaging by dual-channel full-field optical coherence tomography", Proc. SPIE 6429, Coherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XI, 64291N (7 February 2007); doi: 10.1117/12.699916;

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