In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study

Shovan K. Majumder; Steven Gebhart; Reid Thompson M.D.; Kyle D. Weaver M.D.; Mahlon D. Johnson; Wei-Chiang Lin; Anita Mahadevan-Jansen

doi:10.1117/12.724875

7 February 2007 In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study

Shovan K. Majumder, Steven Gebhart, Reid Thompson M.D., Kyle D. Weaver M.D., Mahlon D. Johnson, Wei-Chiang Lin, Anita Mahadevan-Jansen

Author Affiliations +

Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64300F (2007) https://doi.org/10.1117/12.724875
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Recently, optical spectroscopy has shown considerable promise to be used as a potential clinical tool for human brain tumor detection and therapeutic guidance. Our group showed for the first time the possibility of using combined autofluorescence and diffuse reflectance spectroscopy and established its applicability for human brain tumor demarcation in previous in vitro and in vivo studies. We report in this paper the results of a clinical study designed to further evaluate the efficacy of the approach for demarcation of brain tumors and tumor margins from normal brain tissues in intra-operative clinical setting. Using a portable system, optical spectra were collected from the brain of 110 patients undergoing craniotomy at the Vanderbilt University Medical Center. Spectral measurements were taken from multiple sites of tumor core, tumor margin and normal areas of brain tissues and the resulting spectra were correlated with the corresponding histopathologic diagnosis. Using histology as the gold standard, a probabilistic multi-class diagnostic algorithm was developed to simultaneously distinguish tumor core and tumor margin from normal brain tissue sites using independent training and validation sets of data. An unbiased estimate of the accuracy of the model indicates that combined autofluorescence and diffuse reflectance spectroscopy was able to distinguish tumor core and tumor margin from normal brain tissues with an average predictive accuracy of ~88%.

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Shovan K. Majumder, Steven Gebhart, Reid Thompson M.D., Kyle D. Weaver M.D., Mahlon D. Johnson, Wei-Chiang Lin, and Anita Mahadevan-Jansen "In vivo optical detection of brain tumor and tumor margin: a combined autofluorescence and diffuse reflectance spectroscopic study", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300F (7 February 2007); https://doi.org/10.1117/12.724875

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