Needle-probe system for the measurement of tissue refractive index

Adam M. Zysk; Steven G. Adie; Julian J. Armstrong; Matthew S. Leigh; Alexandre Paduch; Freddy T. Nguyen; David D. Sampson; Stephen A. Boppart M.D.

doi:10.1117/12.700955

6 February 2007 Needle-probe system for the measurement of tissue refractive index

Adam M. Zysk, Steven G. Adie, Julian J. Armstrong, Matthew S. Leigh, Alexandre Paduch, Freddy T. Nguyen, David D. Sampson, Stephen A. Boppart M.D.

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Proceedings Volume 6430, Advanced Biomedical and Clinical Diagnostic Systems V; 64300O (2007) https://doi.org/10.1117/12.700955
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Needle-based devices, which are in wide clinical use for needle biopsy procedures, may be augmented by suitable optical techniques for the localization and diagnosis of diseased tissue. Tissue refractive index is one optical contrast mechanism with diagnostic potential. In the case of mammary tissue, for example, recent research indicates that refractive index variations between tissue types may be useful for the identification of cancerous tissue. While many coherence-based forward-sensing devices have been developed to detect scattering changes, none have demonstrated refractive index measurement capabilities. We present a novel needle-based device that is capable of simultaneously measuring refractive index and scattering. Coupled to the sample arm of an optical coherence tomography system, the needle device detects the scattering response and optical pathlength through tissue residing in a fixed-width channel. Near-infrared measurements of tissues and materials with known optical properties using a prototype device will be presented. This work demonstrates the feasibility of integrated in vivo measurement of refractive index and scattering in conjunction with existing clinical needle-based devices.

Citation Download Citation

Adam M. Zysk, Steven G. Adie, Julian J. Armstrong, Matthew S. Leigh, Alexandre Paduch, Freddy T. Nguyen, David D. Sampson, and Stephen A. Boppart M.D. "Needle-probe system for the measurement of tissue refractive index", Proc. SPIE 6430, Advanced Biomedical and Clinical Diagnostic Systems V, 64300O (6 February 2007); https://doi.org/10.1117/12.700955

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KEYWORDS

Refractive index

Tissue optics

Tissues

Scattering

Optical coherence tomography

Interferometry

Channel projecting optics

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