20 February 2007 Near-infrared optical tomography: endoscopic imaging approach
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Proceedings Volume 6431, Multimodal Biomedical Imaging II; 643103 (2007) https://doi.org/10.1117/12.695217
Event: SPIE BiOS, 2007, San Jose, California, United States
Near-infrared optical tomography is an interesting technique of imaging with high blood-based contrast. Unfortunately non-invasive NIR tomographic imaging has been restricted to specific organs like breast that can be transilluminated externally. In this paper, we demonstrate that near-infrared (NIR) optical tomography can be employed at the endoscope-scale, and implemented at a rapid sampling speed that allows translation to in vivo use. A spread-spectral-encoding technique based on a broadband light source is combined with light delivery by linear-to-circular fiber bundle, to provide endoscopic probing of multiple source/detector fibers for tomographic imaging as well as parallel sampling of all source-detector pairs for rapid data acquisition. Endoscopic NIR tomography is demonstrated by use of a 12mm diameter probe housing 8 sources and 8 detectors at 8 Hz frame rate. Transrectal NIR optical tomography by use of tissue specimen is also presented. This novel approach provides the key feasibility studies to allow this blood-based contrast imaging technology to be tried in cancer detection of internal organs via endoscopic interrogation.
© (2007) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Daqing Piao, Daqing Piao, Hao Xie, Hao Xie, Cameron Musgrove, Cameron Musgrove, Charles F. Bunting, Charles F. Bunting, Weili Zhang, Weili Zhang, Guolong Zhang, Guolong Zhang, Ellen B. Domnick-Davidsion, Ellen B. Domnick-Davidsion, Kenneth Eugene Bartels, Kenneth Eugene Bartels, G. Reed Holyoak, G. Reed Holyoak, Sreenivas N. Vemulapalli, Sreenivas N. Vemulapalli, Hamid Dehghani, Hamid Dehghani, Brian W. Pogue, Brian W. Pogue, } "Near-infrared optical tomography: endoscopic imaging approach", Proc. SPIE 6431, Multimodal Biomedical Imaging II, 643103 (20 February 2007); doi: 10.1117/12.695217; https://doi.org/10.1117/12.695217

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