Optical tomography as adjunct to x-ray mammography: methods and results

Mario Khayat; Zahia Ichalalene; Niculae Mincu; Fredéric Leblond; Olga Guilman; Salim Djeziri

doi:10.1117/12.700960

20 February 2007 Optical tomography as adjunct to x-ray mammography: methods and results

Mario Khayat, Zahia Ichalalene, Niculae Mincu, Fredéric Leblond, Olga Guilman, Salim Djeziri

Proceedings Volume 6431, Multimodal Biomedical Imaging II; 64310F (2007) https://doi.org/10.1117/12.700960
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Recent years have seen significant efforts deployed to apply optical imaging techniques in clinical indications. Optical mammography as an adjunct to X-ray mammography is one such application. 3D optical mammography relies on the sensitivity of near-infrared light to endogenous breast chromophores in order to generate in vivo functional views of the breast. This work presents prospective tissue characterization results from a multi-site clinical study targeting optical tomography as an adjunct to conventional mammography. A 2^nd -generation multi-wavelength time-domain acquisition system was used to scan a wide population of women presenting normal or suspicious X-ray mammograms. Application specific algorithms based on a diffusive model of light transport were used to quantify the breast's optical properties and derive 3D images of physiological indices. Using histopathological findings as a gold standard, results confirm that optically derived parameters provide statistically significant discrimination between malignant and benign tissue in wide population of subjects. The methodology developed for case reviews, lesion delineation and characterization allows for better translation of the optical data to the more traditional x-ray paradigm while maintaining efficacy. They also point to the need for guidelines that facilitate correlation of optical data if those results are to be confirmed in a clinical setting.

Citation Download Citation

Mario Khayat, Zahia Ichalalene, Niculae Mincu, Fredéric Leblond, Olga Guilman, and Salim Djeziri "Optical tomography as adjunct to x-ray mammography: methods and results", Proc. SPIE 6431, Multimodal Biomedical Imaging II, 64310F (20 February 2007); https://doi.org/10.1117/12.700960

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