Using fluorescence molecular tomography for multimodality fusion imaging

Sunder Balasubramanian; Brian Carmignani; Naresh Kujala; Domingo Pacheco; Lixin Ma; Charles Smith; Timothy Hoffman; Wynn Volkert; Ping Yu

doi:10.1117/12.701263

8 February 2007 Using fluorescence molecular tomography for multimodality fusion imaging

Sunder Balasubramanian, Brian Carmignani, Naresh Kujala, Domingo Pacheco, Lixin Ma, Charles Smith, Timothy Hoffman, Wynn Volkert, Ping Yu

Author Affiliations +

Proceedings Volume 6431, Multimodal Biomedical Imaging II; 643110 (2007) https://doi.org/10.1117/12.701263
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Multimodality molecular imaging that combines anatomical and functional information has shown promise in development of tumor-targeted pharmaceuticals for cancer detection or therapy. Most multimodality imaging techniques are based on nuclear imaging modalities and MRI or CT. Fluorescence molecular tomography (FMT) is an emerging optical modality for non-invasive functional imaging and early diagnosis of carcinoma. Three-dimensional FMT can differentiate tissue physiological changes in vivo to provide functional information when used in conjunction with cancer cell selectively targeted probes. In this study, we present the design of such a system for multimodality molecular imaging. A frequency domain radio frequency technique based on commercial amateur radio equipment has been developed. A heterodyne method is used to transfer a low frequency oscillation into a single-side-band at radio frequency. The difference in phase, caused by fluorescence photon density wave, is detected between a transmitting fiber and a receiving fiber bundle, and then measured at lower frequency after demodulation. To achieve multimodality molecular imaging, a new fluorescent labeled tumor-targeting probe, fluorescent bombesin conjugates, has been developed with high affinity and specificity for targeting breast cancer cells. The developed multimodality fusion strategy will provide increased sensitivity/specificity for cancer cells, with respect to any single imaging modality.

Citation Download Citation

Sunder Balasubramanian, Brian Carmignani, Naresh Kujala, Domingo Pacheco, Lixin Ma, Charles Smith, Timothy Hoffman, Wynn Volkert, and Ping Yu "Using fluorescence molecular tomography for multimodality fusion imaging", Proc. SPIE 6431, Multimodal Biomedical Imaging II, 643110 (8 February 2007); https://doi.org/10.1117/12.701263

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KEYWORDS

Luminescence

Molecular imaging

Semiconductor lasers

Tomography

Imaging systems

Tissues

Tissue optics

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