Optical coherence tomography in the diagnosis of dysplasia and adenocarcinoma in Barret's esophagus

N. D. Gladkova; E. V. Zagaynova; G. Zuccaro; Margarita V. Kareta; F. I. Feldchtein; Irina V. Balalaeva; Elena B. Balandina

doi:10.1117/12.700254

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12 February 2007 Optical coherence tomography in the diagnosis of dysplasia and adenocarcinoma in Barret's esophagus

N. D. Gladkova; E. V. Zagaynova; G. Zuccaro; Margarita V. Kareta; F. I. Feldchtein; Irina V. Balalaeva; Elena B. Balandina

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Proceedings Volume 6432, Endoscopic Microscopy II; 64320A (2007) https://doi.org/10.1117/12.700254
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Statistical analysis of endoscopic optical coherence tomography (EOCT) surveillance of 78 patients with Barrett's esophagus (BE) is presented in this study. The sensitivity of OCT device in retrospective open detection of early malignancy (including high grade dysplasia and intramucosal adenocarcinoma (IMAC)) was 75%, specificity 82%, diagnostic accuracy - 80%, positive predictive value- 60%, negative predictive value- 87%. In the open recognition of IMAC sensitivity was 81% and specificity were 85% each. Results of a blind recognition with the same material were similar: sensitivity - 77%, specificity 85%, diagnostic accuracy - 82%, positive predictive value- 70%, negative predictive value- 87%. As the endoscopic detection of early malignancy is problematic, OCT holds great promise in enhancing the diagnostic capability of clinical GI endoscopy.

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N. D. Gladkova, E. V. Zagaynova, G. Zuccaro, Margarita V. Kareta, F. I. Feldchtein, Irina V. Balalaeva, and Elena B. Balandina "Optical coherence tomography in the diagnosis of dysplasia and adenocarcinoma in Barret's esophagus", Proc. SPIE 6432, Endoscopic Microscopy II, 64320A (12 February 2007); doi: 10.1117/12.700254; https://doi.org/10.1117/12.700254

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