15 February 2007 Hollow fiber-optic Raman probes for small experimental animals
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Abstract
Two types of hollow fiber-optic probes are developed to measure the in vivo Raman spectra of small animals. One is the minimized probe which is end-sealed with the micro-ball lens. The measured spectra reflect the information of the sample's sub-surface. This probe is used for the measurement of the esophagus and the stomach via an endoscope. The other probe is a confocal Raman probe which consists of a single fiber and a lens system. It is integrated into the handheld microscope. A simple and small multimodal probe is realized because the hollow optical fiber requires no optical filters. The performance of each probe is examined and the effectiveness of these probes for in vivo Raman spectroscopy is shown by animal tests.
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Takashi Katagiri, Yusuke Hattori, Toshiaki Suzuki, Yuji Matsuura, Hidetoshi Sato, "Hollow fiber-optic Raman probes for small experimental animals", Proc. SPIE 6433, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VII, 64330O (15 February 2007); doi: 10.1117/12.702664; https://doi.org/10.1117/12.702664
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