13 February 2007 Prior information in fluorescence molecular tomography based on multispectral fluorescence emission
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Abstract
Fluorescence molecular tomography (FMT) suffers from inherent ill-posedness due to the vast number of possible solutions to the reconstruction problem. To increase the robustness of such a problem one need prior information. We present here a method for rendering a priori information of the position of a fluorescent inclusion inside turbid media. The method utilizes solely two spectral bands within the fluorescence spectrum emitted from the fluorophore. The method is presented and verified using experimental data from a tissue phantom. The confinement is also used to impose weights onto the voxels before the inversion of the linear set of equations describing the FMT problem.
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J. Axelsson, J. Svensson, S. Andersson-Engels, "Prior information in fluorescence molecular tomography based on multispectral fluorescence emission", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340D (13 February 2007); doi: 10.1117/12.699464; https://doi.org/10.1117/12.699464
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