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1 March 2007 A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis
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Abstract
A theoretical framework is presented that allows a lifetime based analysis of the entire temporal diffuse fluorescence response curve from a turbid medium. Optimization studies using singular value decomposition analysis show that direct time domain fluorescence reconstructions are optimally performed using a few points near the peak and rise portions of the temporal response. It is also shown that the initial portion of the fluorescent response curve offers superior contrast-to-noise performance, while the late decay portions offer minimal cross-talk between multiple lifetime components.
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Anand T. N. Kumar, Scott B. Raymond, David A. Boas, and Brian J. Bacskai "A direct approach to time domain fluorescence tomography based on asymptotic lifetime analysis", Proc. SPIE 6434, Optical Tomography and Spectroscopy of Tissue VII, 64340E (1 March 2007); https://doi.org/10.1117/12.699692
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