Mitochondrial dysfunction modulates nonlinear dynamics in liver cell metabolism

V. Krishnan Ramanujan; Brian A. Herman

doi:10.1117/12.701089

7 February 2007 Mitochondrial dysfunction modulates nonlinear dynamics in liver cell metabolism

V. Krishnan Ramanujan, Brian A. Herman

Proceedings Volume 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV; 64360G (2007) https://doi.org/10.1117/12.701089
Event: SPIE BiOS, 2007, San Jose, California, United States

Abstract

Regulatory dynamics of energy metabolism in living cells entails a coordinated response of multiple enzyme networks that operate under non-equilibrium conditions. Here we show that mitochondrial dysfunctions associated with the aging process significantly modify nonlinear dynamical signatures in free radical generation/removal thereby altering energy metabolism in liver cells. Combining high spatial and temporal resolution imaging and bio-energetic measurements, our work provides experimental support to the hypothesis that mitochondria manifest nonlinear dynamical behavior for efficiently regulating energy metabolism in intact cells and any partial or complete reduction in this behavior would contribute to organ dysfunctions including aging process and other disease processes.

Citation Download Citation

V. Krishnan Ramanujan and Brian A. Herman "Mitochondrial dysfunction modulates nonlinear dynamics in liver cell metabolism", Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 64360G (7 February 2007); https://doi.org/10.1117/12.701089

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