7 February 2007 Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect
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Abstract
In order to discuss the relative factors affecting the optical clearing effect of agents on skin tissues, six hydroxy-terminated and saturated alcohols with different refractive index and molecular weight were chosen as the optical clearing agents (OCAs). After being treated by different OCAs, the change of transmitted intensity of porcine skins in vitro was measured by single integrating sphere system. The results showed the optical clearing effects of six OCAs, i.e., glycerol, PEG400, PEG200, 1,3-propylene glycol, 1,4-butanediol and 1-butanol, arranged in the descending order. Based on the above results, the refractive index and molecular weight was further discussed. The optical clearing effect of alcohols has been deduced to have negative correlation with refractive index (r=-0.608), but no correlation with molecular weight (r= 0.008).
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Zhongzhen Mao, Zhongzhen Mao, Ying Zheng, Ying Zheng, Yating Hu, Yating Hu, Wei Lu, Wei Lu, Qingming Luo, Qingming Luo, Dan Zhu, Dan Zhu, } "Influence of refractive index and molecular weight of alcohol agents on skin optical clearing effect", Proc. SPIE 6436, Complex Dynamics and Fluctuations in Biomedical Photonics IV, 64360O (7 February 2007); doi: 10.1117/12.701701; https://doi.org/10.1117/12.701701
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